![]() B: Caffeine-induced Ca 2+ release shows reduced mitochondrial Ca 2+ intake ( mito) in aged donors, relative to young adults.Ī lack of mitochondrial Ca 2+ uptake in muscle during contraction would suggests lower energy production. A: Human muscle cells (green), mitochondria (red), and nuclei (blue). ( Gherardi et al., 2023 | BioR xiv) Aging Leads to Calcium-Related Mitochondrial Dysfunction. The results showed that mitochondrial Ca 2+ uptake was reduced by 45% in aged individuals. They then measured mitochondrial Ca 2+ uptake with a light-sensitive dye. To simulate muscle contraction, the researcher exposed the cells to caffeine, which induces Ca 2+ release. To determine if reduced mitochondrial Ca 2+ intake could contribute to sarcopenia, Gherardi and colleagues examined muscle cells from young and aged donors. Increased energy production is important because low energy contributes to reduced muscle mass and strength, clinical features of sarcopenia that impact physical autonomy and quality of life. During contraction, calcium ions (Ca 2+) are driven into our mitochondria, leading to increased energy production. With every voluntarily movement, our muscles (skeletal muscles) contract. Olive Leaf Extract Improves Calcium-Related Mitochondrial Dysfunction Finally, olive leaf extract is shown to increase calcium uptake and improve the physical performance of aged mice. Additionally, a reduction in a key gene for calcium uptake is correlated with reduced muscle mass and strength in sarcopenia patients. In a preprint from BioR Xiv, Gherardi and colleagues from University of Padova in Italy and the Nestlé Institute of Health Sciences report that mitochondrial calcium uptake declines during aging. While some anti-aging molecules like NAD+ precursors can help prevent chronic diseases indirectly by maintaining mitochondria, a new study shows that mitochondria can be targeted directly with molecules from olive leaves. This is why mitochondrial dysfunction is a hallmark of aging, contributing to chronic diseases like sarcopenia - age-related muscle decline. Our mitochondria produce the energy needed to sustain life. Dietary olive leaf extract improves mitochondrial function, running time, and muscle weight in aged mice. ![]() Muscle samples from older donors show calcium-related mitochondrial defects that correlate with low muscle mass and strength.
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